How it works
It's a strong ghrelin/GH-secretagogue receptor agonist, and it also binds CD36, which has drawn research interest in cardiac tissue distinct from its GH effect.
The evidence
It shows the highest GH-secretagogue potency of the group in studies, plus some cardiac research signals. Human anti-aging/body-composition efficacy is unconfirmed, and receptor desensitization with continued use is a noted issue.
Safety
GH-stimulation effects plus potential cortisol/prolactin elevation; the CD36 cardiac activity is a reason for caution rather than reassurance. Long-term human safety is not established.
FAQ
It's the most potent at the receptor, but potency isn't the same as being safer or better for any goal.
No — investigational.
Sources
This profile summarizes the following. Follow the links to read the originals — and remember that summaries age, so check for newer information.
- Growth hormone-releasing peptides: historical evidence review (PMC)
- GHRP metabolites after nasal administration (PubMed)
Inclusion here is not endorsement of any source's claims; several are cited so you can compare how different outlets characterize the same evidence.
Reviewed by Theo — part of the PepConnection crew.